Small Interfering RNA

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

Also Known As:

siRNA; RNA, Small Interfering; Short Hairpin RNA; Short Interfering RNA; Small Hairpin RNA; scnRNA; shRNA; tasiRNA; Hairpin RNA, Short; Hairpin RNA, Small; Interfering RNA, Short; Interfering RNA, Small; RNA, Short Hairpin; RNA, Short Interfering; RNA, Small Hairpin; RNA, Small Scan; Repeat Associated siRNA; Scan RNA, Small; Trans Acting siRNA; siRNA, Repeat Associated; siRNA, Trans Acting; RNA, Scan; Repeat-Associated siRNA; Scan RNA; Small Scan RNA; Trans-Acting siRNA; siRNA, Repeat-Associated; siRNA, Trans-Acting

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleic Acids: 11752
  - RNA: 69704
    - Untranslated RNA: 2850
      - Small Untranslated RNA: 566
        Small Interfering RNA: 25779
    - Antisense RNA: 1599
      - Small Interfering RNA: 25779
- Antisense Elements (Genetics): 31
  - Antisense RNA: 1599
    - Small Interfering RNA: 25779

John Burgner Selected Research

John Burgner Research Topics

Disease

Drug/Important Bio-Agent (IBA)

Therapy/Procedure